Recently, it has been published in Angewandte Chemie International Edition research I have been involved with my lab mates Marta, and Niels.
For those who are familiar with organic chemistry, you will find the link to the original article below. Hope you enjoy reading it!
Synergistic Diastereo- and Enantioselective Functionalization of Unactivated Alkyl Quinolines with α,β-Unsaturated Aldehydes
Dr. Marta Meazza, Dr. Fernando Tur, Niels Hammer and Prof. Dr. Karl Anker Jørgensen
DOI: 10.1002/anie.201611306
For those who are familiar with organic chemistry, you will find the link to the original article below. Hope you enjoy reading it!
Synergistic Diastereo- and Enantioselective Functionalization of Unactivated Alkyl Quinolines with α,β-Unsaturated Aldehydes
Dr. Marta Meazza, Dr. Fernando Tur, Niels Hammer and Prof. Dr. Karl Anker Jørgensen
DOI: 10.1002/anie.201611306
Find below the abstract:
A fruitful partnership: InCl3 activation of unactivated alkyl quinolines has been combined with organocatalytic activation of α,β-unsaturated aldehydes. The reaction involves two consecutive synergistic catalytic cycles and provides selectively double- or mono-addition products in good yields and high to excellent stereoselectivities. Based on spectroscopic and labeling experiments, the reaction mechanisms are discussed.
A fruitful partnership: InCl3 activation of unactivated alkyl quinolines has been combined with organocatalytic activation of α,β-unsaturated aldehydes. The reaction involves two consecutive synergistic catalytic cycles and provides selectively double- or mono-addition products in good yields and high to excellent stereoselectivities. Based on spectroscopic and labeling experiments, the reaction mechanisms are discussed.
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