Publication in Chemistry: A European Journal (this post is for specialists only)

Recently, it has been published in Chemistry: A European Journal research I have been involved with my lab mates Line, Marta, Jakob and Kim.
For those who are familiar with organic chemistry, you will find the link to the original article below. Hope you enjoy reading it!

Synergistic Catalysis for the Asymmetric [3+2] Cycloaddition of Vinyl Aziridines with α,β-Unsaturated Aldehydes

Line Næsborg, Dr. Fernando Tur, Dr. Marta Meazza, Jakob Blom, Dr. Kim Søholm Halskov and Prof. Dr. Karl Anker Jørgensen

DOI: 10.1002/chem.201604995

Find below the abstract:

The first asymmetric [3+2] cycloaddition of vinyl aziridines with α,β-unsaturated aldehydes, based on synergistic catalysis, is disclosed. This methodology allows the formation of attractive pyrrolidine structures in good yields (up to 84 %), moderate diastereoselectivity, and high enantioselectivity values (up to >99 % ee). Additionally, a tricyclic pyrrolidine core structure found in biologically active molecules was synthesized in a one-pot fashion by using the presented reaction concept. Finally, a mechanistic proposal is outlined.


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