The main compounds from the chiral pool that have been used for this purpose are α-amino acids, hydroxyacids, carbohydrates and terpenes. These natural compounds have some advantageous properties: their optical purity is normally close to 100% they are in general non-toxic and many are inexpensive starting materials.
Organic chemistry bring us the possibility to mimic Nature in order to have access to these natural compounds (with therapeutic properties) or modified and improved efficacy compounds. Easily and giving an example linked to our daily lives, organic synthesis resembles playing Lego®. Organic chemists have a huge toolbox filled with small Lego® bricks (our building blocks). Smart combination and assembly of these Lego® bricks let us to build up more complex structures (our targeted drug). In particular, the chiral pool synthesis rummages in Nature to find these tiny chiral blocks that fit the complex structure we want to build up by means of chemical reactions.
Both examples, Imipenem and Oseltamivir, show us how we can take advantatge of the chiral pool for obtaining chiral drugs very useful for treating diseases.